By coincidence rather than by design, the Swiss chemist Albert Hofmann makes a sensational discovery in the spring of 1943. He realizes that he is dealing with a powerful molecule that will have an impact that reaches far beyond the scientific world. THE SUBSTANCE is an investigation into our troubled relationship with LSD, told from its beginnings to today.
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| Writing | Martin Witz | Writer |
| Directing | Martin Witz | Director |
| Editing | Stefan Kälin | Editor |
| Sound | Russ Jaquith | Sound mixer |
| Sound | Balthasar Jucker | Sound mixer |
| Sound | Marcel Vaid | Music |
| Sound | Roland Widmer | Sound Designer |
| Sound | Stefan Willenegger | Sound Designer |
| Sound | Guido Keller | Sound mixer |
| Crew | Paul Avondet | Title Graphics |
| Crew | Silvana Bezzola Rigolini | Commissioning Editor |
| Crew | Luisella Realini | Commissioning Editor |
| Production | Elda Guidinetti | Producer |
| Production | Andres Pfäffli | Producer |
| Camera | Patrick Lindenmaier | Director of Photography |
| Camera | Pio Corradi | Director of Photography |
