As a result of nuclear testing, gigantic, ferocious mutant ants appear in the American desert southwest, and a father-daughter team of entomologists join forces with the state police officer who first discovers their existence, an FBI agent and, eventually, the US Army to eradicate the menace, before it spreads across the continent, and the world.
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| Production | David Weisbart | Producer |
| Directing | Gordon Douglas | Director |
| Writing | Ted Sherdeman | Screenplay |
| Sound | Bronislau Kaper | Original Music Composer |
| Camera | Sidney Hickox | Director of Photography |
| Editing | Thomas Reilly | Editor |
| Writing | Russell S. Hughes | Adaptation |
| Writing | George Worthing Yates | Story |
| Art | Stanley Fleischer | Art Direction |
| Art | G.W. Berntsen | Set Decoration |
| Costume & Make-Up | Gordon Bau | Makeup Artist |
| Sound | Francis J. Scheid | Sound |
| Costume & Make-Up | Moss Mabry | Wardrobe Designer |
| Costume & Make-Up | Henry Vilardo | Makeup Artist |
| Art | Robert Turner | Props |
