Prospector Harry Farley returns from Alaska to find that his sister, Helen, has gone to New York with Florence, her blind daughter, after being deserted by her husband, Richard Norman. Under the name of Sidney Heaton, Norman has married Blanche Maberly and fallen in with a bootlegging gang while succumbing to the blackmail of Dick Watkins. Helen dies, Heaton kidnaps Florence, but Harry tracks him to the Adirondacks.
Is Lost in a Big City on Netflix? Unfortunately the movie Lost in a Big City is not yet available on Netflix.
| Directing | George Irving | Director |
| Writing | Lillian Case Russell | Scenario Writer |
| Writing | N.S. Woods | Novel |
| Camera | Joseph Settle | Director of Photography |
| Production | J. Stuart Blackton Jr. | Production Manager |
