Ramona is a little girl with a very big imagination and a nose for mischief. Her playful antics keep everyone in her loving family on their toes, including her older sister Beezus, who's just trying to survive her first year of high school. Through all the ups and downs of childhood, Ramona and Beezus learn that anything's possible when you believe in yourself and rely on each other.
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| Production | Alison Greenspan | Producer |
| Writing | Laurie Craig | Screenplay |
| Writing | Nick Pustay | Screenplay |
| Writing | Beverly Cleary | Novel |
| Production | Denise Di Novi | Producer |
| Directing | Elizabeth Allen Rosenbaum | Director |
| Production | Brad Van Arragon | Co-Producer |
| Camera | John Bailey | Director of Photography |
| Art | Brent Thomas | Production Design |
| Editing | Jane Moran | Editor |
| Art | Carol Lavallee | Set Decoration |
| Art | Shannon Grover | Art Direction |
| Costume & Make-Up | Patricia Hargreaves | Costume Design |
| Costume & Make-Up | Monica Huppert | Makeup Artist |
| Costume & Make-Up | Donna Bis | Hairstylist |
| Sound | Julia Michels | Music Supervisor |
| Production | Christian Kaplan | Casting |
| Production | Coreen Mayrs | Casting |
| Production | Heike Brandstatter | Casting |
| Production | J. Michael Williams | Unit Production Manager |
| Crew | Garvin Cross | Stunt Coordinator |
| Crew | Ryan Ennis | Stunt Coordinator |
| Editing | Ken Terry | Additional Editing |
| Art | Martina Javorova | Set Designer |
| Writing | Adrien van Viersen | Storyboard |
| Art | Iesza Jessica Jordan | Art Department Assistant |
| Art | Madeleine Grant | Art Department Assistant |
| Camera | Jim Van Dijk | Camera Operator |
| Camera | Jim Van Dijk | Steadicam Operator |
| Camera | Karl Herrmann | Camera Operator |
| Camera | Alan Markfield | Still Photographer |
| Sound | Shane Connelly | Sound Mixer |
| Sound | Michael Hibberson | Boom Operator |
| Directing | Patti Henderson | Script Supervisor |
| Sound | John Morris | Supervising Sound Editor |
| Sound | Erik Aadahl | Sound Designer |
| Sound | Skip Lievsay | Sound Re-Recording Mixer |
| Sound | Gregg Landaker | Sound Re-Recording Mixer |
| Lighting | Mike Moyer | Gaffer |
| Lighting | Bill Dawson | Best Boy Electric |
| Costume & Make-Up | Sandra J. Blackie | Assistant Costume Designer |
| Costume & Make-Up | Keith A. Parent | Set Costumer |
| Production | Neil Robertson | Location Manager |
| Production | Susan Crawford | Production Coordinator |
| Crew | Rory Cutler | Special Effects Coordinator |
| Crew | Steven Michael Adams | Special Effects |
| Art | Jesse Joslin | Construction Coordinator |
| Art | Keith McCulloch | Construction Foreman |
| Crew | Lorraine Jamison | Unit Publicist |
| Sound | John Marquis | Sound Effects Editor |
| Sound | David V. Butler | Dialogue Editor |
| Art | David Dowling | Property Master |
| Sound | Mark Mothersbaugh | Original Music Composer |
