Determined to prove its superiority, a bio-engineered Pokémon called Mewtwo lures Ash, Pikachu and others into a Pokemon match like none before.
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| Directing | Kunihiko Yuyama | Director |
| Writing | Takeshi Shudo | Screenplay |
| Production | Choji Yoshikawa | Producer |
| Camera | Hisao Shirai | Director of Photography |
| Writing | Satoshi Tajiri | Original Story |
| Sound | Shinji Miyazaki | Music |
| Sound | Hirokazu Tanaka | Music |
| Visual Effects | Izumi Shimura | Animation Director |
| Visual Effects | Sayuri Ichiishi | Character Designer |
| Art | Kunihiko Yuyama | Storyboard Artist |
| Visual Effects | Fumiyo Kimura | Key Animation |
| Visual Effects | Yuzo Sato | Key Animation |
| Visual Effects | Satoshi Kubo | Key Animation |
| Visual Effects | Yasuhide Maruyama | Key Animation |
| Visual Effects | Katsuichi Nakayama | Key Animation |
| Visual Effects | Akiko Nakamura | Key Animation |
| Visual Effects | Kaori Kunii | Key Animation |
| Visual Effects | Masao Nakata | Key Animation |
| Visual Effects | Yuriko Chiba | Key Animation |
| Visual Effects | Junko Isaka | Key Animation |
| Visual Effects | Masami Takebuchi | Key Animation |
| Visual Effects | Tomoko Takei | Key Animation |
| Visual Effects | Midori Nagaoka | Key Animation |
| Visual Effects | Masahiro Sekiguchi | Key Animation |
| Visual Effects | Masao Suwa | Key Animation |
| Visual Effects | Tsunenaka Nozaki | Key Animation |
| Visual Effects | Yoshihiro Nagamori | Key Animation |
| Visual Effects | Midori Yamakubo | Key Animation |
| Visual Effects | Tetsuro Kaku | Key Animation |
| Visual Effects | Yumi Chiba | Key Animation |
| Visual Effects | Yoshihiro Osugi | Key Animation |
| Visual Effects | Nori Nakamura | Key Animation |
| Visual Effects | Hiroshi Kawaguchi | Key Animation |
| Visual Effects | Masaya Fujimori | Key Animation |
| Visual Effects | Koji Fukasawa | Key Animation |
| Visual Effects | Katsuyuki Tamura | Key Animation |
| Visual Effects | Kazuaki Mori | Key Animation |
| Visual Effects | Takuya Matsumoto | Key Animation |
| Visual Effects | Masatsugu Takeda | Key Animation |
| Visual Effects | Yuji Mukoyama | Key Animation |
| Visual Effects | Shoichi Masuo | Key Animation |
| Visual Effects | Eiko Saito | Key Animation |
| Visual Effects | Hiroko Kazui | Key Animation |
| Visual Effects | Kazumi Sato | Key Animation |
| Visual Effects | Hiromi Niioka | Key Animation |
| Visual Effects | Satoru Iriyoshi | Key Animation |
| Visual Effects | Satomi Kitahara | Key Animation |
| Visual Effects | Mamiko Nakanishi | Key Animation |
| Visual Effects | Hideaki Maniwa | Key Animation |
| Visual Effects | Toshiharu Kumaoka | Key Animation |
| Visual Effects | Tadaaki Miyata | Key Animation |
| Visual Effects | Etsuhito Mori | Key Animation |
| Visual Effects | Masaaki Iwane | Key Animation |
| Visual Effects | Izumi Shimura | Key Animation |
| Visual Effects | Masaru Fukumoto | Animation Director |
| Visual Effects | Eikichi Takahashi | Animation Director |
| Visual Effects | Masaya Fujimori | Animation Director |
| Visual Effects | Yoshiaki Yanagida | Animation Director |
| Visual Effects | Shunya Yamada | Animation Director |
| Visual Effects | Norihiro Matsubara | Animation Director |
