Having lost their status and credibility five years after covering New York City with gooey roasted marshmallows in Ghostbusters (1984), the city's former heroes and once-popular spirit-hunters struggle to keep afloat, forced to work odd jobs. However, when Dana and her baby have yet another terrifying encounter with the paranormal, it is up to Peter Venkman and his fearless team of supernatural crime fighters to step up and save the day. Once more, humankind is in danger, as rivers of slimy psycho-reactive ectoplasm, paired with the dreadful manifestation of evil sixteenth-century tyrant Vigo the Carpathian, threaten to plunge the entire city into darkness. Is the world ready to believe? Can the Ghostbusters save us for the second time?
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| Writing | Harold Ramis | Screenplay |
| Writing | Dan Aykroyd | Screenplay |
| Directing | Ivan Reitman | Director |
| Production | Ivan Reitman | Producer |
| Camera | Michael Chapman | Director of Photography |
| Crew | Danny Aiello III | Stunts |
| Sound | Randy Edelman | Original Music Composer |
| Crew | Billy D. Lucas | Stunts |
| Crew | Jon Curtis Price | Special Effects |
| Crew | Lane Leavitt | Stunts |
| Crew | Steven Lambert | Stunts |
| Crew | Richard E. Butler | Stunts |
| Costume & Make-Up | John Dods | Makeup Artist |
| Crew | Bob Minor | Stunts |
| Production | Michael Chinich | Casting |
| Crew | Jo Martin | Visual Effects Editor |
| Costume & Make-Up | Stephen Abrums | Makeup Artist |
| Costume & Make-Up | Gandhi Bob Arrollo | Makeup Artist |
| Costume & Make-Up | Gloria Gresham | Costume Design |
| Costume & Make-Up | Frank Bianco | Hairstylist |
| Costume & Make-Up | John M. Elliott Jr. | Key Makeup Artist |
| Art | Bo Welch | Production Design |
| Art | Tom Duffield | Art Direction |
| Art | Cheryl Carasik | Set Decoration |
| Costume & Make-Up | Peggy Semtob | Hairstylist |
| Costume & Make-Up | Marlene D. Williams | Hairstylist |
| Crew | Erik Cord | Stunts |
| Visual Effects | Janet Healy | Visual Effects Producer |
| Sound | David M. Ice | Sound Editor |
| Editing | Chris Jargo | Dialogue Editor |
| Camera | Robert Edesa | Camera Operator |
| Editing | Donn Cambern | Editor |
| Editing | Sheldon Kahn | Editor |
| Visual Effects | Dennis Muren | Visual Effects Supervisor |
| Directing | Peter Giuliano | First Assistant Director |
| Art | Greg John Callas | Construction Coordinator |
| Art | Nick Navarro | Set Designer |
| Costume & Make-Up | G. Tony Scarano | Costume Supervisor |
| Sound | Bruce Foster | Sound Editor |
| Sound | Fred Judkins | Supervising Sound Editor |
| Crew | Joel Kramer | Stunt Coordinator |
| Costume & Make-Up | Oda Groeschel | Costume Supervisor |
| Art | Richard Hoffenberg | Construction Foreman |
| Sound | Tom C. McCarthy | Supervising Sound Editor |
| Production | Pamela Cederquist | Production Coordinator |
| Camera | Michael Genne | Camera Operator |
| Lighting | Leslie J. Kovacs | Chief Lighting Technician |
| Camera | Bruce McBroom | Still Photographer |
| Sound | Peter Afterman | Music Supervisor |
| Art | Greg Papalia | Set Designer |
| Art | Bill MacSems | Property Master |
| Art | William A. Petrotta | Property Master |
| Sound | Burton Weinstein | Sound Editor |
| Art | Rick Heinrichs | Set Designer |
| Sound | Richard Friedman | Supervising ADR Editor |
| Sound | Solange S. Schwalbe | Sound Editor |
| Visual Effects | Pamela Easley | Visual Effects Coordinator |
| Crew | Ed Mirassou | Propmaker |
| Sound | Don S. Walden | Sound Editor |
| Directing | Faye Brenner | Script Supervisor |
| Sound | Steve Cantamessa | Boom Operator |
| Crew | Kurt Bryant | Stunts |
| Crew | Jophery C. Brown | Stunts |
| Writing | Dan Aykroyd | Characters |
| Writing | Harold Ramis | Characters |
| Art | Edmund E. Villa | Assistant Property Master |
| Crew | Tony Brubaker | Stunt Double |
| Crew | Andy Gill | Stunts |
| Crew | Gary J. Wayton | Stunt Double |
| Crew | Debbie Evans | Stunts |
| Crew | Michael M. Vendrell | Stunts |
| Crew | Gene Harrison | Stunts |
| Crew | Kerrie Cullen | Stunts |
| Crew | Leon Delaney | Stunts |
| Crew | Paula Wayton | Stunts |
| Crew | Deborah Watkins | Stunts |
| Crew | Lori Crowder | Stunts |
| Crew | Leah Creed | Stunts |
| Crew | Vince Deadrick Sr. | Stunts |
| Crew | Kym Washington Longino | Stunts |
| Crew | Sven-Ole Thorsen | Stunts |
| Crew | Larry Holt | Stunts |
| Crew | Sandy Richman | Stunts |
| Crew | David Webster | Stunts |
| Crew | Roydon Clark | Stunts |
| Crew | Anthony G. Schmidt | Stunts |
| Crew | William T. Lane | Stunts |
| Crew | Peter Bucossi | Stunts |
| Crew | Clifford Happy | Stunts |
| Crew | Marguerite Happy | Stunts |
| Crew | Fred Lerner | Stunts |
| Crew | Frank James Sparks | Stunts |
| Crew | Michael Russo | Stunts |
| Crew | Bill Anagnos | Stunts |
| Crew | Frank Ferrara | Stunts |
| Crew | Donna Garrett | Stunts |
| Crew | Wally Crowder | Stunts |
| Crew | Roger Creed | Stunts |
| Crew | Ceci Vendrell | Stunts |
| Crew | Jery Hewitt | Stunts |
| Crew | Phil Neilson | Stunts |
| Crew | John Robotham | Stunts |
| Crew | Mick O'Rourke | Stunts |
| Directing | Sue Fellows | Assistant Director Trainee |
| Production | Dorothy O'Leary | Casting Assistant |
| Camera | Gene Kearney | Key Grip |
| Camera | Sandy Williams | Dolly Grip |
| Art | Tom Miller | Assistant Property Master |
| Camera | Bob Munoz | Best Boy Grip |
| Lighting | Benny McNulty | Best Boy Electrician |
| Lighting | Ken W. Ballantine | Electrician |
| Lighting | E. Christopher Reed | Electrician |
| Lighting | Eric Smith | Electrician |
| Art | Ann Harmon | Art Department Assistant |
| Costume & Make-Up | Jennifer Butler | Costumer |
| Costume & Make-Up | Adrienne Manhan | Costumer |
| Lighting | Brent Poe | Electrician |
| Costume & Make-Up | Le Dawson | Costumer |
| Lighting | Gregory Peters | Electrician |
| Camera | Robert Sordal | Dolly Grip |
| Crew | Craig Pinkard | Transportation Coordinator |
| Production | Catherine Cederquist | Production Assistant |
| Art | Francis N. 'Lucky' Costello | Standby Painter |
| Crew | Richard Wood | Special Effects |
| Crew | Mark Jennings | Cableman |
| Production | Anne Prager | Production Assistant |
| Crew | Dick Johnson | Transportation Captain |
| Production | Ginny Warner | Production Secretary |
| Sound | Mark Gordon | Sound Editor |
| Directing | Cyd Adams | Second Second Assistant Director |
| Production | Stephanie Kahn | Production Assistant |
| Crew | Chuck Gaspar | Special Effects |
| Crew | Joe Day | Special Effects |
| Production | Gaetano Vaccaro | Production Assistant |
| Sound | Gene S. Cantamessa | Production Sound Mixer |
| Production | Stuart Fink | Publicist |
| Production | Matthew Gould | Production Assistant |
| Sound | Greig McRitchie | Orchestrator |
| Production | David Forbes | Production Assistant |
| Sound | William Hartman | Sound Editor |
| Directing | Ira S. Rosenstein | Second Second Assistant Director |
| Production | Jim Vatis | Production Assistant |
| Production | Gordon A. Webb | Unit Production Manager |
| Production | Bernie Brillstein | Executive Producer |
| Camera | Larry Hezzelwood | First Assistant Camera |
| Production | Gordon A. Webb | Associate Producer |
| Production | Michael C. Gross | Executive Producer |
| Camera | Dylan Goss | Camera Loader |
| Camera | Tim Sasaki | Second Assistant Camera |
| Art | Jack Johnson | Production Illustrator |
| Camera | Greg Walters | Second Assistant Camera |
| Production | Joe Medjuck | Executive Producer |
| Directing | Christine Larson-Nitzsche | Second Assistant Director |
| Directing | Michael D. Moore | Second Unit Director |
| Art | Thom Enriquez | Production Illustrator |
| Production | Sheldon Kahn | Associate Producer |
| Art | John Warnke | Assistant Art Director |
| Art | Chuck McSorley | Leadman |
| Crew | Mary Peters | Stunts |
