After Megamind, a highly intelligent alien supervillain, defeats his long-time nemesis Metro Man, Megamind creates a new hero to fight, but must act to save the city when his "creation" becomes an even worse villain than he was.
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| Directing | Tom McGrath | Director |
| Production | Lara Breay | Producer |
| Production | Denise Nolan Cascino | Producer |
| Production | Stuart Cornfeld | Executive Producer |
| Production | Ben Stiller | Executive Producer |
| Sound | Lorne Balfe | Original Music Composer |
| Sound | Hans Zimmer | Original Music Composer |
| Writing | Andy Schuhler | Storyboard |
| Visual Effects | Simon Rodgers | Visual Development |
| Writing | Shane Prigmore | Storyboard |
| Sound | Kevin Kaska | Orchestrator |
| Art | David James | Production Design |
| Crew | Derek Drymon | Thanks |
| Crew | Cameron Hood | Thanks |
| Crew | Kyle Jefferson | Thanks |
| Crew | Mike Mitchell | Thanks |
| Crew | Guillermo Navarro | Thanks |
| Crew | Debbie L. O'Keeffe | Thanks |
| Crew | Gary Trousdale | Thanks |
| Crew | Conrad Vernon | Thanks |
| Crew | Guillermo del Toro | Creative Consultant |
| Production | Holly Edwards | Associate Producer |
| Crew | Justin Theroux | Creative Consultant |
| Editing | Michael Andrews | Editor |
| Production | Leslee Feldman | Casting |
| Art | Timothy Lamb | Art Direction |
| Production | Kira Shea Smithson | Administration |
| Visual Effects | Chris Bancroft | Animation |
| Visual Effects | Martin P. Hopkins | Animation |
| Visual Effects | Morgan R. Kelly | Animation |
| Visual Effects | Rani Naamani | Animation |
| Visual Effects | Ross Burgess | Animation |
| Crew | Nazia Khan | Actor's Assistant |
| Crew | Marc Bonilla | Additional Music |
| Crew | Michael A. Levine | Additional Music |
| Sound | Gavin Greenaway | Conductor |
| Production | Ariga Parseghian | Finance |
| Production | Vicki Hunter | Finance |
| Production | Terri Anderson | Finance |
| Sound | John T. Cucci | Foley |
| Lighting | Amanda Johnstone-Batt | Lighting Artist |
| Sound | Tom Boyd | Musician |
| Sound | Andrew Crowley | Musician |
| Sound | Jonathan Evans-Jones | Musician |
| Sound | Paul Kegg | Musician |
| Sound | Roger Linley | Musician |
| Sound | Steve Mair | Musician |
| Sound | Michael C. Mason | Musician |
| Sound | Dan Newell | Musician |
| Sound | Steve Schaeffer | Musician |
| Production | Christine Nguyen | Production Coordinator |
| Production | Bonnie Lemon | Executive In Charge Of Production |
| Directing | Erik Pope | Script Supervisor |
| Art | Ariandy Chandra | Title Designer |
| Visual Effects | Scott B. Peterson | Visual Effects |
| Art | Doug Pierce | Set Designer |
| Crew | Ken Ball | CG Supervisor |
| Crew | Annmarie Koenig | CG Supervisor |
| Crew | Robert Lurye | CG Supervisor |
| Crew | Michael McNeill | CG Supervisor |
| Crew | Fatima Robinson | Choreographer |
| Crew | Kathy Nelson | Executive Music Producer |
| Crew | Mona Shokrai | Legal Services |
| Crew | Alissa Rowinsky Wright | Legal Services |
| Crew | John Hanashiro | Post Production Supervisor |
| Crew | Andrew Birch | Post-Production Manager |
| Crew | Gregg Carrier | Software Engineer |
| Crew | Patrick Kelly | Software Engineer |
| Crew | Margaret A. Decker | Software Engineer |
| Crew | Dave Burgess | Supervising Animator |
| Crew | Anthony Hodgson | Supervising Animator |
| Crew | Sean Mahoney | Supervising Animator |
| Crew | Jason Spencer-Galsworthy | Supervising Animator |
| Crew | David Torres | Supervising Animator |
| Crew | Corban Gossett | Supervising Technical Director |
| Crew | Greg Gibson | Systems Administrators & Support |
| Crew | Rain Angeles | Systems Administrators & Support |
| Crew | Shawn Bohonos | Systems Administrators & Support |
| Crew | Dave Dinsmore | Systems Administrators & Support |
| Crew | Dj Downey | Systems Administrators & Support |
| Crew | Alireza Estakhrian | Systems Administrators & Support |
| Crew | Bart Feliciano | Systems Administrators & Support |
| Crew | Othieno Okong'o | Systems Administrators & Support |
| Crew | John Finklea | Temp Music Editor |
| Crew | David Hail | Unit Publicist |
| Directing | Liska Ostojic | Script Coordinator |
| Editing | John Dorst | Assistant Editor |
| Editing | Robert W. Hedland | Assistant Editor |
| Editing | Daniel Ortiz | Assistant Editor |
| Editing | William M. Steinberg | Assistant Editor |
| Editing | Lynn Hobson | Associate Editor |
| Editing | Christopher Knights | Associate Editor |
| Editing | Michelle Mendenhall | Associate Editor |
| Editing | Madison Sellers | Editorial Production Assistant |
| Lighting | Sucheta Bhatawadekar | Lighting Artist |
| Lighting | Clint Colver | Lighting Artist |
| Lighting | Mark A. Decker | Lighting Artist |
| Lighting | Antoine Deschamps | Lighting Artist |
| Lighting | Kirsten Drummond | Lighting Artist |
| Lighting | Julien Forest | Lighting Artist |
| Lighting | Navjit Singh Gill | Lighting Artist |
| Lighting | Dorien Gunnels | Lighting Artist |
| Lighting | Glen Gustafson | Lighting Artist |
| Lighting | George Ho | Lighting Artist |
| Lighting | Noel Hocquet | Lighting Artist |
| Lighting | Gregory Jennings | Lighting Artist |
| Lighting | Kurt Kaminski | Lighting Artist |
| Lighting | Oth Khotsimeuang | Lighting Artist |
| Lighting | Jennifer Leigh King | Lighting Artist |
| Lighting | Amber Stewart Lunderville | Lighting Artist |
| Lighting | Pietro Materossi | Lighting Artist |
| Lighting | Cristian Moras | Lighting Artist |
| Lighting | Hannah Sherman | Lighting Artist |
| Lighting | Prapanch Swamy | Lighting Artist |
| Lighting | Ka Yaw Tan | Lighting Artist |
| Lighting | Ryan Michael Todd | Lighting Artist |
| Lighting | Lisa M. Tse | Lighting Artist |
| Lighting | Benjamin Venancie | Lighting Artist |
| Lighting | Lori Williams | Lighting Artist |
| Lighting | Hanwei Wu | Lighting Artist |
| Lighting | Emily Yi | Lighting Artist |
| Lighting | Doug Yoshida | Lighting Artist |
| Lighting | Alfred Young | Lighting Artist |
| Lighting | Matthieu Grospiron | Lighting Artist |
| Lighting | Yuko Okumura | Lighting Artist |
| Lighting | Jack Lilburn | Lighting Coordinator |
| Lighting | William E. Arias | Master Lighting Artist |
| Lighting | Max Bruce | Master Lighting Artist |
| Lighting | Sebastien Chort | Master Lighting Artist |
| Lighting | Kevin Edwards | Master Lighting Artist |
| Lighting | Amy Rae Jones | Master Lighting Artist |
| Lighting | David C. Lawson | Master Lighting Artist |
| Lighting | Jimmy Maidens | Master Lighting Artist |
| Lighting | Marc Miller | Master Lighting Artist |
| Lighting | Tony Mitzelfelt | Master Lighting Artist |
| Lighting | Ronman Yiu Yan Ng | Master Lighting Artist |
| Lighting | Eli Rod | Master Lighting Artist |
| Lighting | Milton E. Rodriguez-Rios | Master Lighting Artist |
| Lighting | Geri Smith | Master Lighting Artist |
| Lighting | Jung Jin Song | Master Lighting Artist |
| Lighting | Jessi Stumpfel | Master Lighting Artist |
| Lighting | Gina Warr | Master Lighting Artist |
| Lighting | Gabriel White | Master Lighting Artist |
| Production | Matt Robertson | Administration |
| Production | Brittany Cope | Casting Assistant |
| Production | Mollie Gamo | Casting Assistant |
| Production | Christi Soper Hilt | Casting Associate |
| Production | Darci Zalvin | Executive In Charge Of Production |
| Production | Betty Tom | Production Accountant |
| Production | Lauren Blackshear | Production Coordinator |
| Production | Alyson Blume | Production Coordinator |
| Production | Matthew C. Campbell | Production Coordinator |
| Production | Tim Kwan | Production Coordinator |
| Production | Shane Mulholland | Production Coordinator |
| Production | Rachel Slansky | Production Coordinator |
| Production | Yimi Tong | Production Coordinator |
| Production | Andre de Oliviera Araujo | Production Manager |
| Production | Maude Lewis | Production Manager |
| Production | Kate Spencer | Production Manager |
| Production | Jannette Eng | Production Supervisor |
| Production | Danielle Helsaple | Production Supervisor |
| Production | David Isetta | Production Supervisor |
| Production | Diana K. Lee | Production Supervisor |
| Production | Camille Leganza | Production Supervisor |
| Production | Kelly Matthews | Production Supervisor |
| Production | Robyn Mesher | Production Supervisor |
| Production | Trinity Murphy | Production Supervisor |
| Production | Meredith Narrowe | Production Supervisor |
| Production | Malia P. Russell | Production Supervisor |
| Production | Steven Schweickart | Production Supervisor |
| Production | Ryan Genji Thomas | Production Supervisor |
| Production | Jessie Carbonaro | Production Supervisor |
| Sound | Roy Latham | ADR & Dubbing |
| Sound | Carlos Sotolongo | ADR & Dubbing |
| Sound | R.J. Kizer | ADR Editor |
| Sound | Andy Sisul | First Assistant Sound Editor |
| Sound | James Ashwill | Foley |
| Sound | Dan O'Connell | Foley |
| Sound | Ramiro Belgardt | Music Editor |
| Sound | Peter Oso Snell | Music Editor |
| Sound | Chris Clad | Musician |
| Sound | George Doering | Musician |
| Sound | Jake Walker | Musician |
| Sound | Rick Giovinazzo | Orchestrator |
| Sound | Carl Rydlund | Orchestrator |
| Sound | Slamm Andrews | Scoring Mixer |
| Sound | Daniel Fresco | Scoring Mixer |
| Sound | Daniel Kresco | Scoring Mixer |
| Sound | P.K. Hooker | Sound Effects Editor |
| Sound | John Marquis | Sound Effects Editor |
| Sound | Tom Lalley | Sound Engineer |
| Sound | Ryan Cole | Sound Recordist |
| Sound | Tighe Sheldon | Sound Recordist |
| Sound | Anna Behlmer | Sound Re-Recording Mixer |
| Sound | Andy Nelson | Sound Re-Recording Mixer |
| Sound | Susan Dudeck | Supervising ADR Editor |
| Sound | Erik Aadahl | Supervising Sound Editor |
| Sound | Ethan van der Ryn | Supervising Sound Editor |
| Visual Effects | Mike Beaulieu | Animation |
| Visual Effects | Julien Bocabeille | Animation |
| Visual Effects | Ludovic Bouancheau | Animation |
| Visual Effects | Bailey Brent | Animation |
| Visual Effects | Nelson Brown | Animation |
| Visual Effects | Laurent Caneiro | Animation |
| Visual Effects | Christopher Lee Capel | Animation |
| Visual Effects | Guillermo Careaga | Animation |
| Visual Effects | Paul Chung | Animation |
| Visual Effects | Katrina Conwright | Animation |
| Visual Effects | Melanie Cordan | Animation |
| Visual Effects | Michelle Cowart | Animation |
| Visual Effects | Cameron Fielding | Animation |
| Visual Effects | Alexander Fleisig | Animation |
| Visual Effects | Ken Fountain | Animation |
| Visual Effects | W. Jacob Gardner | Animation |
| Visual Effects | Maciek Gliwa | Animation |
| Visual Effects | Ryan Gong | Animation |
| Visual Effects | Tomoyuki Harashima | Animation |
| Visual Effects | Mariko Hoshi | Animation |
| Visual Effects | Jeffrey Joe | Animation |
| Visual Effects | Scott Lafleur | Animation |
| Visual Effects | Peer Lemmers | Animation |
| Visual Effects | Tommie Löfqvist | Animation |
| Visual Effects | Stephen Melagrano | Animation |
| Visual Effects | Irene Parkins | Animation |
| Visual Effects | Rebecca Perez | Animation |
| Visual Effects | Tyler Phillips | Animation |
| Visual Effects | Ron Pucherelli | Animation |
| Visual Effects | Luke Randall | Animation |
| Visual Effects | Mark Roennigke | Animation |
| Visual Effects | Cory Rogers | Animation |
| Visual Effects | Ben Rush | Animation |
| Visual Effects | Kevan Shorey | Animation |
| Visual Effects | David Spivack | Animation |
| Visual Effects | Dane Stogner | Animation |
| Visual Effects | Philip To | Animation |
| Visual Effects | Nara Youn | Animation |
| Visual Effects | Nicasio Nakamine | Animation Production Assistant |
| Visual Effects | Jason Ryan | Animation Supervisor |
| Visual Effects | Andy Bialk | Character Designer |
| Visual Effects | Devin Crane | Character Designer |
| Visual Effects | Sylvain Deboissy | Character Designer |
| Visual Effects | Timothy Lamb | Character Designer |
| Visual Effects | Chris Reccardi | Character Designer |
| Visual Effects | Tony Siruno | Character Designer |
| Visual Effects | Peter Farson | Creature Technical Director |
| Visual Effects | Cara Malek | Creature Technical Director |
| Visual Effects | Cliff B. Mitchell | Creature Technical Director |
| Visual Effects | Stephan Osterburg | Creature Technical Director |
| Visual Effects | Sven Pohle | Creature Technical Director |
| Visual Effects | Sebastien Potet | Creature Technical Director |
| Visual Effects | Kendal Sager | Creature Technical Director |
| Visual Effects | Nico Sanghrajka | Creature Technical Director |
| Visual Effects | Paul Timpson | Creature Technical Director |
| Visual Effects | Priscilla Chiu Yee Tsang | Creature Technical Director |
| Visual Effects | Dick Walsh | Creature Technical Director |
| Visual Effects | Jeff Wang | Creature Technical Director |
| Visual Effects | Guido Zimmermann | Creature Technical Director |
| Visual Effects | Drago Avdalovic | Creature Technical Director |
| Visual Effects | Adrian Tsang | Creature Technical Director |
| Visual Effects | Soongu Kwon | Modeling |
| Visual Effects | Steve McGrath | Modeling |
| Visual Effects | Paul Schoeni | Modeling |
| Visual Effects | Jung Jin Kang | Modeling |
| Visual Effects | Jeff Wagner | Modeling |
| Visual Effects | John Allwine | VFX Artist |
| Visual Effects | Benjamin Andersen | VFX Artist |
| Visual Effects | Shinsaku Arima | VFX Artist |
| Visual Effects | Greg Beckman | VFX Artist |
| Visual Effects | Steven Blakey | VFX Artist |
| Visual Effects | Julie Anne Brame | VFX Artist |
| Visual Effects | Markus Burki | VFX Artist |
| Visual Effects | Robert Chen | VFX Artist |
| Visual Effects | Wes Chilton | VFX Artist |
| Visual Effects | Tyson Erze | VFX Artist |
| Visual Effects | Landon Gray | VFX Artist |
| Visual Effects | Laurent Kermel | VFX Artist |
| Visual Effects | Robert Kopinsky | VFX Artist |
| Visual Effects | Jaemin Lee | VFX Artist |
| Visual Effects | Olive Lin | VFX Artist |
| Visual Effects | Yancy Lindquist | VFX Artist |
| Visual Effects | Gustav Melich | VFX Artist |
| Visual Effects | August Meredith | VFX Artist |
| Visual Effects | William Opdyke | VFX Artist |
| Visual Effects | Alex Patanjo | VFX Artist |
| Visual Effects | John Patton | VFX Artist |
| Visual Effects | Stephanie Siebert | VFX Artist |
| Visual Effects | Osamu Takehiro | VFX Artist |
| Visual Effects | Stuart Tett | VFX Artist |
| Visual Effects | Katie Van Maanen | VFX Artist |
| Visual Effects | Zubin Wadia | VFX Artist |
| Visual Effects | Jason Waltman | VFX Artist |
| Visual Effects | Philippe Denis | VFX Supervisor |
| Visual Effects | Richard Daskas | Visual Development |
| Visual Effects | Goro Fujita | Visual Development |
| Visual Effects | Alex Hagelis | Visual Development |
| Visual Effects | Kory Heinzen | Visual Development |
| Visual Effects | Chin Ko | Visual Development |
| Visual Effects | Travis Koller | Visual Development |
| Visual Effects | Bryan Gregg LaShelle | Visual Development |
| Visual Effects | Peter Maynez | Visual Development |
| Visual Effects | Sam Michlap | Visual Development |
| Visual Effects | Sunil Pant | Visual Development |
| Visual Effects | Jason William Scheier | Visual Development |
| Visual Effects | Stan Seo | Visual Development |
| Visual Effects | James Wood Wilson | Visual Development |
| Visual Effects | Raymond Zibach | Visual Development |
| Visual Effects | Shaun Graham | Visual Effects |
| Visual Effects | Fangwei Lee | Visual Effects |
| Visual Effects | Kyle Maxwell | Visual Effects |
| Visual Effects | Zeki Melek | Visual Effects |
| Visual Effects | Nikita Pavlov | Visual Effects |
| Visual Effects | Jason Rickwald | Visual Effects |
| Visual Effects | Matt Titus | Visual Effects |
| Visual Effects | Reny Preussker | Visual Effects Coordinator |
| Crew | Mark Donald | Supervising Animator |
| Writing | David G. Derrick Jr. | Story Artist |
| Crew | Mackenzie Thompson | Software Engineer |
| Writing | Alan Schoolcraft | Writer |
| Writing | Brent Simons | Writer |
